Mechanistic insights into anticancer properties of oligomeric proanthocyanidins from grape seeds in colorectal cancer
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Oligomeric proanthocyanidins from grape seeds effectively inhibit ultraviolet-induced melanogenesis of human melanocytes in vitro.
The oligomeric proanthocyanidins (OPCs) from grape seeds are expected to be novel and potent anti-oxidants that more effectively protect skin cells against oxidative stress. UV-induced oxidative stress is considered to promote melanogenesis and serious skin damage. However, the effect of OPCs on UV-induced melanogenesis is still unknown. To investigate the role of OPCs on melanogenesis of human...
متن کاملSecondary metabolites in durian seeds: oligomeric proanthocyanidins.
Ethanolic extract of durian seeds was fractionated by reverse phase flash column chromatography and the fractions characterized by electrospray ionization mass spectroscopy. Among a few unknown compounds collected, oligomeric proanthocyanidins (OPCs) were found to be one of the main compounds. Based on this result, the OPCs were purified the first time from the durian seeds using standard proce...
متن کاملExtraction and Characterization of Proanthocyanidins from Grape Seeds
Grape seed contains many polyphenolic compounds that have potential health-promoting benefits. Among these compounds are proanthocyanidins, also known as condensed tannins, which is a class of flavanols. The basic structural building blocks of flavanols are polyhydroxyflavan-3-ol units linked together by C-C bonds. They are widely distributed in plants but grape seed has very high contents. Thi...
متن کاملSUMMARY OF DATA FOR CHEMICAL SELECTION Oligomeric Proanthocyanidins from Grape Seeds and Pine Bark BASIS OF NOMINATION TO THE CSWG
Based on the structures of identified active ingredients, the phenolic compounds extracted from grape seeds and pine bark would not be expected to be genotoxic. Indeed, the inventor of pycnogenol states that this product was tested in Salmonella typhimurium and was negative. Substantial health claims for grape seed and pine bark extracts, including some studies showing tumor inhibition, make th...
متن کاملSUMMARY OF DATA FOR CHEMICAL SELECTION Oligomeric Proanthocyanidins from Grape Seeds and Pine Bark BASIS OF NOMINATION TO THE CSWG
Based on the structures of identified active ingredients, the phenolic compounds extracted from grape seeds and pine bark would not be expected to be genotoxic. Indeed, the inventor of pycnogenol states that this product was tested in Salmonella typhimurium and was negative. Substantial health claims for grape seed and pine bark extracts, including some studies showing tumor inhibition, make th...
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ژورنال
عنوان ژورنال: Carcinogenesis
سال: 2018
ISSN: 0143-3334,1460-2180
DOI: 10.1093/carcin/bgy034